Robling, Alexander G., PhD
- St. Mary's College of Maryland, BA, 1992
- George Washington University, MA, 1995
- University of Missouri - Columbia, PhD, 1998
- Indiana University School of Medicine, Postdoctoral Fellowship, 1999-2001
- 1999 Postdoctoral Fellow, Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN.
- 2001 Assistant Scientist, Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN.
- 2003 Assistant Scientist, Department of Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN.
- 2003 Graduate Faculty, Indiana University School of Medicine
- 2004 Assistant Professor, Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN.
- 2007 Graduate Faculty, Purdue University, West Lafayette, IN.
- 2008 Assistant Professor (adjunct), Department of Biomedical Engineering, Indiana University/Purdue University at Indianapolis (IUPUI), Indianapolis, IN.
- 2010 Associate Professor (with tenure), Department of Anatomy & Cell Biology, Indiana University School of Medicine; and Department of Biomedical Engineering, IUPUI, Indianapolis, IN.
My laboratory works on treatments for metabolic and genetic bone diseases. We use molecular genetic approaches in rodents to identify new ways to make bone stronger. One particular approach that we have focused on is mechanobiology. Mechanobiology merges the older science of mechanics with the newer and emerging disciplines of molecular biology and genetics. At the center of mechanobiology is the cellular process of mechanotransduction, or the way cells sense and respond to mechanical forces. We research how mechanical loads signal bone cells to build stronger bones. Our research program has led us to the Wnt signaling pathway as a major regulator of mechanotransduction. Current projects are centered around the particular steps in the Wnt cascade that are activated by mechanical stimuli and ultimately lead to increased anabolism.
- Robling AG, Niziolek PJ, Baldridge LA, Condon KW, Allen MR, Alam I, Mantila SM, Gluhak-Heinrich J, Bellido TM, Harris SE, Turner CH (2008) Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 283:5866-75.
- Yan J, Chen S, Zhang Y, Li X, Li Y, Wu X, Yuan J, Robling AG, Kapur R, Chan RJ, Yang FC (2008) Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1. Hum Mol Genet 17:936-48.
- Munugalavadla V, Vemula S, Krishnan S, Sims EC, Chen S, Yan J, Li H, Niziolek PJ, Takemoto C, Robling AG, Yang FC, Kapur R (2008) p85α subunit of class IA PI-3kinase regulates the expression of multiple genes involved in osteoclast maturation and migration. Mol Cell Biol. 23:7182-98.
- O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. (2008) Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS ONE 13:e2942.
- Robling AG, Childress P, Yu J, Cotte J, Heller A, Philp BK, Bidwell JP (2009) Nmp4/CIZ suppresses parathyroid hormone-induced increases in trabecular bone. J Cell Physiol 219:734-43.
- Gattone VH, Sinders RM, Hornberger TS, Robling AG (2009) Rapamycin inhibits late progression, not initial development of murine nephronophthisis. Kidney Int 76:178-82.
- Niziolek PJ, Murthy S, Ellis SN, Sukhija KB, Hornberger TA, Turner CH, Robling AG (2009) Rapamycin impairs trabecular bone acquisition from high-dose but not low-dose intermittent parathyroid hormone treatment. J Cell Physiol, 221:579-85.
- Gilmore JL,Gonterman RM, Menon K, Lorch G, Riese DJ II, Robling AG, Foley J (2009) Reconstitution of amphiregulin–epidermal growth factor receptor signaling in lung squamous cell carcinomas activates PTHrP gene expression and contributes to cancer-mediated diseases of the bone. Mol Cancer Res 7:1714-28.
- Chennimalai-Kumar N, Dantzig JA, Jasiuk IM, Robling AG, Turner CH (2009) Numerical Modeling of Long Bone Adaptation due to Mechanical Loading: Correlation with Experiments. Ann Biomed Eng: 38:594-604.
- Childress P, Robling AG, Bidwell JP (2009) Nmp4/CIZ: Road block at the intersection of PTH and load. Bone 46:259-66.
- Komatsu DE, Mary MN, Schroeder RJ, Robling AG, Turner CH, Warden SJ. (2010) Modulation of Wnt signaling influences fracture repair. J Orthop Res, 28:928-36.
- Philip BK, Childress P, Robling AG, Heller A, Nawroth PP, Bierhaus A, Bidwell JP (2009) RAGE Supports Parathyroid Hormone-Induced Gains In Femoral Trabecular Bone. Am J Physiol Endocrinol Metab. 298:E714-25.
- McAteer ME, Niziolek PJ, Ellis SN, Alge DL, Robling AG. (2010) Mechanical stimulation and intermittent parathyroid hormone treatment induce disproportional osteogenic, geometric, and biomechanical effects in growing mouse bone. Calcif Tissue Int. 86:389-96.