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Bidwell, Joseph P., PhD

Education

  • B.S. Bowling Green State University Biology 1975
  • Ph.D. Case Western Reserve University Phys Chem 1983
  • Postdoctoral Marine Biological Lab/WHOI Biology 1983-88
  • Postdoctoral Mayo Clinic Cell Biol 1988-90
  • Postdoctoral University Mass. Med. Center Mol. Biol 1990-93


Academic Appointments

  • 1999-2009: IUSM Dept of Anatomy & Cell Biology Associate Professor
  • 1999-2006: IUSD Dept of Periodontics Associate Professor
  • 1993-1999: IUSM Dept of Anatomy & Cell Biology Assistant Professor
  • 1993-1999: IUSD Dept of Periodontics Assistant Professor

 

Professional Societies

  • American Society of Cell Biology 1992-2008
  • American Society of Bone and Mineral Research 1989-present
  • American Association of the Advancement of Science 1986-present
  • American Chemical Society 1978-2008


Honors

  • Shellhammer Teaching Award Department of Anatomy & Cell Biology IUSM 2010
  • Visiting Professor; Chulalongkorn and Naresuan Universities Thailand,1999 & 2004
  • Prestigious External Award Recognition (PEAR) IUSM 2003
  • R.R. Bensley Award, American Association of Anatomists 2002
  • The Distinguished Faculty Award for Research, IUSD 1999
  • Visiting Professor: Meikai University, Sakado, Japan 1997

 

CV in PDF format

Ten million people in the US suffer from osteoporosis, a disease of reduced bone mass and debilitating fractures. Teriparatide (parathyroid hormone, PTH) is the only FDA-approved drug that replaces bone lost to osteoporosis. However, it is not the drug of first choice primarily due to cost. A cost-effective strategy for delivering teriparatide should include developing shorter courses of treatment that yield similar efficacy as longer-term therapy. Moreover, this might alleviate concerns over tachyphylaxis, where extended use of PTH results in diminished benefits. A weight-bearing exercise program may maximize teriparatide potency and clinical utility since combining PTH with mechanical loading synergizes bone growth in rodents. Identifying signaling pathways that regulate the response of the skeleton to both stimuli may be key to maximizing the impact of either stimulus alone, or to mimicking the effects of both stimuli via pharmacologic targeting.

The transcriptional repressor Nmp4/CIZ (nuclear matrix protein 4/cas interacting zinc finger protein) is a PTH-responsive and mechanically-responsive architectural transcription factor (ATF) that inhibits bone-anabolic genes. ATFs regulate gene activity by bending DNA. Disabling Nmp4/CIZ in mice enhances PTH-mediated gains in trabecular bone without compromising gains in cortical bone. Additionally, Nmp4/CIZ-null mice are immune to disuse-induced bone loss. Thus, inhibiting Nmp4/CIZ in patients may abbreviate and/or enhance teriparatide therapy, provide a prophylactic to disuse osteoporosis, and enhance the anabolic tonic derived from exercise. Our primary research focus is to determine how Nmp4/CIZ regulates bone response to PTH and/or changes in load. Nmp4/CIZ suppresses osteoid synthesis by repressing transcription of bone matrix genes. It is also found in the cytoplasm and binds to mechanosensitive focal adhesion proteins. Therefore it may transduce PTH- or load-stimulated changes in bone cell adhesion into alterations in DNA conformation and transcription. Our studies include the search for Nmp4/CIZ targets. Within this context we are presently focusing on the Wnt/beta-catenin/LEF1 and HMGB1/RAGE signaling pathways. These data will facilitate the development of strategies for enhancing teriparatide potency, reveal new targets in the anabolic pathway, and provide a more cost-effective anabolic therapy.

  1. Childress P, Robling AG, Bidwell JP. Nmp4/CIZ: road block at the intersection of PTH and load. Bone. 46: 259-266, 2010
  2. Philip BK, Childress PJ, Robling AG, Heller A, Nawroth PP, Bierhaus A, Bidwell JP. RAGE supports parathyroid hormone-induced gains in femoral trabecular bone. Am J Physiol Endocrinol Metab. 298: E714-725, 2010
  3. Yang Z, Bidwell JP, Young SR, Gerard-O'Riley R, Wang H, Pavalko FM. Nmp4/CIZ inhibits mechanically induced beta-catenin signaling activity in osteoblasts. J Cell Physiol. 2010 223: 435-41, 2010
  4. Wang H, Young SR, Gerard-O’Riley R, Hum JM, Yang Z, Bidwell JP, Pavalko FM Blockade of TNFR1 signaling: a role of oscillatory fluid shear stress in osteoblasts J Cell Physiol (in press)

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