Xu, Zao C., MD, PhD


  • Guangzhou Medical College, China, MD, 1982
  • Sun Yet-Sen University of Medical Sciences, China, MS, 1986
  • University of Tennessee, Memphis, PhD, 1990
  • University of Tennessee, Memphis, Postdoctoral Fellowship, 1990-1992


Academic Appointments

  • 2008 – Present Director, Confucius Institute in Indianapolis, IUPUI.
  • 2004 – Present Professor, Indiana University School of Medicine. Department of Anatomy and Cell Biology, Department of Neurology.
  • 1998 - 2004 Associate Professor, Indiana University School of Medicine. Department of Anatomy and Cell Biology, Department of Neurology.
  • 1992 - 1997 Assistant Professor, University of Tennessee, Memphis. Department of Neurology.
  • 1990 – 1992 Postdoctoral Fellow, University of Tennessee, Memphis,
  • 1982 - 1984 Instructor, Guangzhou Medical College, Department of Anatomy, Guangzhou, China.


CV in PDF format

Our research focuses on the pathogenesis of neuronal injury after cerebral ischemia or traumatic brain injury using in vivo and in vitro preparations.   The alterations of synaptic transmission and ion channels after the insult and their roles in neuronal damage/survival will be studied using electrophysiological, morphological and molecular biological approaches.  We also collaborate with other investigators on pain and spinal cord injury researches.

  • Deng, P., Zhang, Y and Xu, Z. C. (2008) Inhibition of Ih in striatal cholinergic interneurons early after transient forebrain ischemia. J Cerebr Blood F Met. 28: 939-947.
  • Zhang, Y., Deng, P., Ruan, Y. and Xu, Z. C. (2008) Dopamine D1-like receptors depress
  • excitatory synaptic transmissions in striatal neurons after transient forebrain ischemia. Stroke 39: 2370-2376 .
  • Lei, Z., Deng, P. and Xu, Z. C. (2008) Regulation of Kv4.2 channels by glutamate in cultured hippocampal neurons. J. Neurochem. 106: 182-192.
  • Fan, Y., Deng, P., Wang, Y., Lu, H., Xu, Z. C. and Schulz, P. E. (2008) Transient cerebral ischemia increases CA1 pyramidal neurons excitability. Exp. Neurol. 212:415-21.
  • Wei, X., Ma, Z., Fontanilla, CV., Zhao, L., Xu, ZC., Taggliabraci, V., Johnstone, B., Dodel, RC., Farlow, MR. and Du, Y. (2008) Caffeic acid phenethyl ester prevents cerebellar granule neurons (CGNS) against glutamate-induced neurotoxicity. Neurosci. 155:1098-1105.
  • Ruan, Y., Lei, Z., Fan, Y., Zou, B. and Xu, ZC. (2009) Diversity and Fluctuation of spine morphology in CA1 pyramidal neurons after transient global ischemia. J. Neurosci. Res, 87:61-68.
  • Li, Y., Lei, ZG and Xu, Z.C. (2009) Enhancement of inhibitory synaptic transmission in large aspiny neurons after transient cerebral ischemia. Neurosci. 159: 670-681.
  • Noe, J., Petrusca, D.N., Rush, J.I., Deng, P., VanDemark, M., Berdyshev, E.V., Gu, Y., Smith, P., Pilewsky, J., Wagner, E., Natarajan, V., Xu, Z.C., and Petrache, I. (2009) CFTR regulation of intracellular PH and ceramides is required for lung endothelial cell apoptosis. Am J. Resp. Cell Mol Biol. Epub.
  • Nguyen, D., Deng, P., Matthews, EA., Kim, D., Feng, G., Dickenson, AH., Xu, ZC and Z. David Luo (2009) Enhanced Pre-Synaptic Glutamate Release in Deep-Dorsal Horn Contributes to Calcium Channel Alpha-2-Delta-1 Protein-Mediated Spinal Sensitization and Behavioral Hypersensitivity. Molecular Pain 5.6.
  • Liang, R., Pang, ZP., Deng, P. and Xu, ZC. (2009) Transient enhancement of inhibitory synaptic transmission in hippocampal CA1 pyramidal neurons after cerebral ischemia. Neurosci. 160:412-418.
  • Deng, P., Pang, ZP., Lei, Z. and Xu, ZC (2009) Excitatory Roles of Protein Kinase C in Striatal Cholinergic Interneurons. J. Neurophysiol. 102:2453-2461.
  • Xu, H., He, M., Pang, X., Xu, ZC., Piesman, J. and Yang, XF. (2010) Characterization of the highly regulated antigen BBA05 in the enzootic cycle of Borrelia burgdorferi. Infection and Immunity 78:100-109.
  • Lei, Z., Deng, P., Li, Y. and Xu, ZC (2010) Down regulation of Kv4.2 channels mediated by NR2B-containing NMDA receptors in cultured hippocampal neurons. Neurosci. 165:350-362.
  • Zhan, L., Wang, T., Li, W., Xu, Z. C., Sun, W. and Xu, A. (2010) Activation of Akt/Fox0 signaling pathway contributes to induction of neuroprotection against transient global cerebral ischemia by hypoxic pre-conditioning in adult rats. J. Neurochem 114:897-908.
  • Liao, W.P., Shi, Y. W., Long Y. S., Zeng, Y., Li, T., Yu, M. J., Su, T., Deng, P., Lei, Z., Xu S. J., Deng, W. Y., Liu X. R., Sun W. W., Yi, Y. H, Xu, Z. C. and Duan S. (2010) Partial epilepsy with antecedent febrile seizures and seizure aggravation by antiepileptic drugs: Associated with loss of function of NaV 1.1. Epilepsia 51(9): 1669-78.
  • Li, Y., Blanco, G., Lei, Z., and Xu, Z. C. (2010) Increased GAD expression in the striatum after transient cerebral ischemia. Molecular and Cellular Neurosci. In press.

Department of Anatomy & Cell Biology | IU School of Medicine | 635 Barnhill Drive, MS 5035 | Indianapolis, IN 46202 | (317) 274-7494