Renal Biology Research
- Evan, Andrew P., PhD - Dr. Evan has studied structural-functional correlations in the kidney for over 40 years and is a recognized expert in quantitative ultrastructure of the nephron, the structure and function of the renal microvasculature and the pathophysiology of acute and chronic renal disease with special emphasis on kidney stone disease. He is Chancellor's Professor Emeritus, is Senior Investigator at the Methodist Research Institute and is Co-Director of the International Kidney Stone Institute.
Key personnel (Evan):
Philip Blomgren has developed a computer assisted technique to quantitate tissue damage in an intact kidney and is highly skilled in all forms of digital image analysis.
Sharon Bledsoe has special skills in light and electron microscopy for routine stains and immuno-electron microscopy. She has developed protocols that allow one to analyze 2 millimeter renal biopsies of whole kidneys by micro-computed tomography (µCT).
- Gattone II, Vincent H., PhD - Dr. Gattone has a long-standing interest in renal pathophysiology through the use of animal models. He has worked in this field for over 30 years with over 100 peer-reviewed journal articles. His current interests include Pathogenesis of polycystic kidney disease-PKD including epigenetic factors that contributes to disease progression. These studies include identification of contributory factors that have now resulted in the identification of agents to treat PKD, pathogenesis of the multiorgan pathology of Meckel Syndome, and the role of extracellular matrix in the progression of the cystic phenotype. Vince is also involved in studies on the pathogenesis of tubulointerstitial fibrosis associated with chronic kidney diseases (CKD), and multiorgan pathology in CKD-Matrix Bone Disorder-MBD for which he has developed animal models. In addition, Vince is active in research on the pathogenesis of kidney stone disease including proteomics and biomarkers for human idiopathic hypercalcemic stone formation, and spontaneous rodent models of nephrolithiasis. Vince is a member of several professional societies related to his kidney disease and microscopy interests. He consults for BioPharma companies and the PKD Foundation and sits on several journal editorial boards. His IUSOM teaching is in the Medical Gross Anatomy course and he is Course Director of the Electron Microscopy course and lecturing in a few other graduate courses. He is Director of the IUSM Electron Microscopy Center and holds an adjunct appointment as Professor of Biology in the Purdue University School of Science.
Key personnel (Gattone):
Caroline Miller, Manager of the Electron Microscopy Center
- McAteer, James A., PhD - Dr. McAteer has a long-standing interest in establishing in vitro model test systems. His current focus is translational research to improve shock wave lithotripsy for the non-invasive removal of kidney stones. Jim is a member of the Scientific Advisory Council of the International Kidney Stone Institute, is an organizer and proceedings editor for the International Urolithiasis Research Symposium series, and is a Fellow of the Acoustical Society of America. Jim’s academic responsibilities include service as Course Director of Medical and Graduate Histology, Chair of the A&CB Primary Committee (P&T), member of the IUSM Faculty Promotion Committee. He is a member of the Executive Committee of Project SEED—a high school research participation program. Ongoing projects focus on developing practical treatment protocols to improve stone breakage outcomes and reduce adverse effects in shock wave lithotripsy (SWL) with emphasis on improving acoustic coupling, determining the SW-threshold for renal injury, characterizing the advantages and limitations of clinical lithotripters, and understanding how treatment parameters affect SW action.
Key personnel (McAteer):
Guangyan Li, Ph.D. (Physics, University of Mississippi) - Dr. Li is an expert in assessment of underwater acoustic fields.
- Williams Jr., James C., PhD - Kidney stones affect a large number of Americans, with about 12% of people having at least one stone in their lifetime, and half of these people will have more than one stone. Stones are rarely life-threatening, but they cause intense pain and often require surgical procedures to be removed. The causes of kidney stones are not fully understood, but it is obvious that the causes are many, and thus the treatments for stones will also be diverse.