Organ, Jason M., PhD
- 1999: AB, University of Missouri, Anthropology
- 2002: MA, University of Missouri, Anthropology
- 2007: PhD, Johns Hopkins University School of Medicine, Functional Anatomy and Evolution
- 2007-2008: Postdoctoral Research Fellow, Kennedy Krieger Research Institute and Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine
- 2008-2012: Assistant Professor of Anatomy (Basic Science Educator), Department of Surgery, Center for Anatomical Science and Education, Saint Louis University School of Medicine, St. Louis, MO
- 2010-2013: Research Collaborator, Division of Mammals, National Museum of Natural History, Smithsonian Institution, Washington, DC
- 2012-Present: Assistant Professor, Department of Anatomy & Cell Biology, Indiana University School of Medicine, Indianapolis, IN
- 2000-2012: American Association of Physical Anthropologists
- 2004-Present: American Association of Anatomists
- 2013-Present: American Society for Bone and Mineral Research
- 2006: Mildred Trotter Prize for Mineralized Tissue Research, American Association of Physical Anthropologists
- 2011: Keith & Marion Moore Young Anatomist's Publication Award, American Association of Anatomists
- 2011: Young Faculty Participation Award, American Association of Anatomists
- 2013: Short-Term Visiting Scholarship, American Association of Anatomists
The Organ Lab at IUSM studies the relationship between bone and muscle mechanics at the whole-organ level, and how tissue-level mechanisms influence whole-organ function. We utilize numerous in vivo model systems to understand how disease, exercise, and pharmaceutical intervention influence bone and muscle structure, cellular activity, and biomechanical properties. We study these properties in the context of chronic kidney disease, osteogenesis imperfecta, and normal postnatal ontogeny, using a variety of techniques: imaging (CT, DXA, X-ray), histology (static and dynamic histomorphometry), muscle electrophysiology (in vivo ankle torque, in vitro whole muscle contractility), and bone mechanical testing (bending, compression, reference point indentation). The Organ Lab is funded by the NIH and IUSM/Showalter Research Trust.
Gallant MA, Brown DB, Organ JM, Allen MR, Burr DB. 2013. Reference-point indentation correlates with bone toughness assessed using whole-bone traditional mechanical testing. Bone 53:301-305. PMCID: PMC3563255. http://hdl.handle.net/1805/4624.
Patel BA, Ruff CB, Simons ELR, Organ JM. 2013. Humeral cross-sectional shape in suspensory primates and sloths. Anat Rec 296:545-556. PMID: 23408647.
Aref M, Gallant MA, Organ JM, Wallace JM, Newman CL, Burr DB, Brown DM, Allen MR. 2013. In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs. Bone 56:449-453. PMCID: PMC3873633. http://hdl.handle.net/1805/3375.
Moe SM, Chen NX, Newman CL, Gattone II VH, Organ JM, Chen X, Allen MR. 2014. A comparison of calcium to zoledronic acid for improvement of cortical bone in an animal model of CKD. J Bone Miner Res 29:902-910. PMCID: PMC3940692. http://hdl.handle.net/1805/3644.
Allen MR, Newman CL, Smith E, Brown DM, Organ JM. 2014. Variability of in vivo reference point indentation in skeletally mature inbred rats. J Biomech 47:2504-2507. PMCID: PMC4096655. http://hdl.handle.net/1805/4299.
Deane AS, Russo GA, Muchlinski MN, Organ JM. 2014. Caudal vertebral body articular surface morphology correlates with functional tail use in anthropoid primates. J Morphol 275:1300-1311. PMID: 24916635. http://hdl.handle.net/1805/4533.
Moe SM, Chen NX, Newman CL, Organ JM, Kneissel M, Kramer I, Gattone II VH, Allen MR. 2015. Anti-sclerostin antibody treatment in a rat model of progressive renal osteodystrophy. J Bone Miner Res 30:499-509. PMCID: PMC4333005. http://hdl.handle.net/1805/5544.
Lee DY, Wetzsteon RJ, Zemel BS, Shults J, Organ JM, Foster BJ, Herskovitz RM, Foerster DL, Leonard MB. 2015. Muscle torque relative to cross-sectional area and the functional muscle-bone unit in children and adolescents with chronic disease. J Bone Miner Res 30:575-583. PMCID: PMC4532328.
Rupert JE, Rose JA, Organ JM, Butcher MT. 2015. Forelimb muscle architecture and myosin isoform composition in the groundhog (Marmota monax). J Exp Bio 218:194-205. PMID: 25452499.
Srisuwananukorn A, Allen MR, Brown DM, Wallace JM, Organ JM. 2015. In vivo reference point indentation measurement variability in skeletally mature inbred mice. BoneKEy Reports 4(712):1-5. PMCID: PMC4478874
Organ JM, Srisuwananukorn A, Price P, Joll JE, Biro KC, Rupert JE, Chen NX, Avin KG, Moe SM, Allen MR. 2016. Reduced skeletal muscle function is associated with decreased fiber cross-sectional area in the Cy/+ rat model of progressive kidney disease. Nephrol Dial Transplant 31:223-230. PMID: 26442903
Allen MR, McNerny EMB, Organ JM, Wallace JM. 2015. True gold or pyrite: a review of reference point indentation for assessing bone mechanical properties in vivo. J Bone Miner Res 30:1539-1550.