My research interests are: effects of nutrition-related diseases including diabetes mellitus, chronic kidney disease, and obesity on bone and mineral metabolism and bone quality; nutrition and exercise for primary and secondary prevention of osteoporosis throughout the life course, particularly through maximizing peak bone mass during adolescence and young adulthood; and endocrinology of bone metabolism in nutrition-related diseases.
My current research interest is in the mechanisms that are implicated in PTH mediated bone formation and resorption. Of the many different pathways, my focus is on wnt/?-catenin signaling and PI3K/PTEN/Akt signaling and their effects on bone building capacities of PTH. I am also interested in the catabolic properties of PTH treatment, and how those mechanisms differ from the anabolic effects of the same hormone.
My current research is focused on extracorporeal shock wave lithotripsy (ESWL), which is a well-established and common procedure that uses ultrasound to pulverize urinary stones from the outside of body. The overall goal is to develop practical treatment protocols that will improve outcomes and reduce adverse effects in ESWL. Most of research activities are carried out in our Lithotripsy Laboratory using a Dornier HM3 electrohydraulic research lithotripter, a Dornier Compact S electromagnetic lithotripter and other lithotripters available from our collaborators.